Quantitative phase microscopy allows us to measure the modification of wavefront while traversing a nanoparticle. It brings additional information on the refractive index of nanoparticles. Associated with the algorithm of Machine Learning, my system can characterize/ identify the nature of nanoparticles and biological samples. It can also be a method of dry mass quantification of biological samples, including the infectious virus (HIV-1, SARS-CoV-2,...).

Nguyen et al., Small, 2023, 2304564

Keywords : Phase Microscopy - Nanoparticles - Biological quantification

My project is to develop a method of spectroscopy for individual moving nanoparticles in solution.  To do so, the 3D position of nanoparticle, localized by digital holographic microscopy, is used as a feed-back to re-center the signal of the particle on the detector of the spectrometer during its movement in real-time.

The system is then applied for the studies of galvanic exchange on moving silver nanoparticles, showing the variation of NP's size and its resonance wavelength during the reaction.

Nguyen et al., ACS Nano, 2022, 16(9)

Nguyen et al., Opt. Express, 2022, 30(24)

Keywords : Holography - Spectroscopy - Nanoparticles